Synthetic Route of 116861-31-5, These common heterocyclic compound, 116861-31-5, name is tert-Butyl (3-chloropropyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-3 (40 mg, 97 pmol) and 19-1-1A (23 mg, 116 pmol) in DMF (300 uL) was added K2CO3 (27 mg, 194 pmol). The mixture was mixture was stirred at room temperature for 16 hr. The reaction cooled and diluted with DCM (5 mL). The solution was filtered and the filtrate was concentrated under reduced pressure. The crude was purified by flash column chromatography (ISCO, silica, l2g, ethyl acetate in hexanes) to afford 15 (18.9 mg, 34% yield).
Statistics shows that tert-Butyl (3-chloropropyl)carbamate is playing an increasingly important role. we look forward to future research findings about 116861-31-5.
Reference:
Patent; TP THERAPEUTICS, INC.; ROGERS, Evan W.; CUI, Jingrong Jean; ZHAI, Dayong; ZHANG, Han; UNG, Jane; DENG, Wei; WHITTEN, Jeffrey; (146 pag.)WO2019/126121; (2019); A1;,
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