In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 125414-41-7 as follows. HPLC of Formula: C8H17NO4
The suspension of powdered KOH (3.05 g) and anhydrous THF (15 mL) was cooled to 0 C, Ar protection. Compound 2 (2.06 g) was dissolved in dry THF (10 mL) Was added dropwise to the reaction solution, After adding 0 reaction 15min, A solution of 4.7 mL of bromopropyne was added dropwise, 0 reaction 5min after the temperature to 35 C overnight, Deionized water (100 mL) was added, CH2Cl2 extraction, Saturated brine washing, Anhydrous Na2SO4 dried, filter, concentrate, Column separation, A yellow liquid 3 (2.467 g, 88%) was obtained.
According to the analysis of related databases, 125414-41-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangxi University; Wang, Mian; Wang, Jianyi; Chen, Zhengjun; (18 pag.)CN106554378; (2017); A;,
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