Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 869494-16-6, name is tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H18N2O2
A mixture of (R)-4-(6-fluoropyridin-3 -yl)-6-(2-hydroxypropoxy)pyrazolo[ 1,5 – a]pyridine-3-carbonitrile (Intermediate P66; 100 mg, 0.320 mmol) 3,6-diaza- bicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester (95.2 mg, 0.480 mmol) and K2C03(s) (443 mg, 3.20 mmol) in DMSO (1601 tL) was stirred for 3 d at 80 °C. The reaction mixture was cooled to ambient temperature, then diluted with water (10 mL), and extracted with DCM (4 x 10 mL). The combined organic extracts were washed with brine (10 mL), then dried over anhydrous Na2SO4(), filtered, and concentrated in vacuo. The crude residue was purified by silica chromatography (using 50-100percent EtOAc in Hexanes as the gradient eluent) to cleanly provide the title compound (97 mg, 62percent yield). MS (apci) m/z = 491.2 (M+H).
According to the analysis of related databases, 869494-16-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; TANG, Tony P.; REN, Li; (668 pag.)WO2018/71447; (2018); A1;,
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