Related Products of 1314538-55-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1314538-55-0, name is Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Boc20 (178 uL, 0.77 mmol) was added to a solution of (4-(aminomethyl)phenyl)boronic acid hydrochloride (143 mg, 0.77 mmol) and Cs2C03 (665 mg, 2.04 mmol) in DME (10 mL) and water (1.0 mL) at rt. After being stirred at rt for 30 min, Suzuki coupling was carried out as follow: 2-chloro-N-(3- (lH-imidazol-l-yl)propyl)-3-phenylquinoxaline-6-carboxamide (201 mg, 0.54 mmol) (prepared according to Example 3, step 7) and Pd(dppf)Cl2? CH2C12 (42.0 mg, 51.4 muiotaetaomicron) were added to the reaction mixture. The mixture was heated at 100 C for 10 h under microwave irradiation. After cooling, the mixture was poured into saturated aqueous solution of NaHC03 and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgS04 and concentrated in vacuo. The residue was purified by NH silica gel chromatography to give teri-butyl [4-(6-{[3-(lH-imidazol-l- yl)propyl]carbamoyl}-3-phenylquinoxalin-2-yl)benzyl]carbamate (187 mg, 65%, H NMR (300 MHz, DMSO-i/6) delta 1.23-1.52 (m, 9 H), 2.00-2.12 (m, 2 H), 3.32-3.39 (m, 2 H), 4.05^1.19 (m, 4 H), 6.91 (s, 1 H), 7.10-7.30 (m, 3 H), 7.32-7.77 (m, 9 H), 8.12-8.38 (m, 2 H), 8.69 (d, J= 1.3 Hz, 1 H), 8.91 (t, J= 5.2 Hz, 1 H)
The chemical industry reduces the impact on the environment during synthesis Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; GIGSTAD, Kenneth, M.; CARDIN, David, P.; HIRAYAMA, Takaharu; HIROSE, Masaaki; HU, Yongbo; KAKEI, Hiroyuki; LEE, Hong, Myung; MOTOYAJI, Takashi; NII, Noriyuki; SHI, Zhan; VYSKOCIL, Stepan; WATANABE, Hiroyuki; WO2015/161142; (2015); A1;,
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