Adding a certain compound to certain chemical reactions, such as: 104060-23-3, name is N-Boc-2-(4-Aminophenyl)ethanol, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104060-23-3, Safety of N-Boc-2-(4-Aminophenyl)ethanol
To a solution of tert-butyl (4-(2-hydroxyethyl)phenyl)carbamate (6.90 g, 30 mmol) and imidazole (2.45 g, 36 mmol) in DCM (100 mL), was added dropwise chlorotriisopropylsilane (6.36 g, 33 mmol) at rt. The reaction mixture was stirred for lh and then water was added. The organic layer was washed with brine dried over Na2504 and concentrated under vacuum. The residue was purified by column chromatography (silica gel, DCM) to afford tert-butyl (4-(2-((triisopropylsilyl)oxy)ethyl)phenyl)carbamate (11.7 g, 99%) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-2-(4-Aminophenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth A.; VERNER, Erik; WO2014/182829; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics