127-77-5, name is 4-Amino-N-phenylbenzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C12H12N2O2S
To a suspension of 2,4-bis(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one (150 mg, 0.627 mmol) in isopropanol (4 mL) were added 4-amino-N-phenylbenzenesulfonamide (327 mg, 1.316 mmol) and 2 drops of conc. HCl, and the reaction mixture was stirred at reflux for 10 hours. The reaction mixture was cooled, diluted with MeOH (10 mL) and treated with aqueous NaHCO3 solution to adjust pH to 7. The precipitate was collected by filtration and washed with water, and purified using column chromatography (silica gel, 0 to 80% 3:1 DCM:MeOH/DCM) to give 190 mg of product as a pale brown solid. MS (ES) m/z = 440.2 [M+1]+; 1H NMR (400 MHz, DMSO-d6) delta ppm 2.53 (s, 3H), 6.36 (d, J = 7.34 Hz, 1H), 7.01 – 7.16 (m, 3H), 7.20 – 7.28 (m, 2H), 7.60 (d, J = 7.34 Hz, 1H), 7.73 – 7.81 (m, 2H), 7.86 – 7.99 (m, 2H), 10.20 (br.s, 1H), 12.00 (br s, 1H), 12.25 (s, 1H); 13C NMR (101 MHz, DMSO-d6) delta ppm 14.22, 101.22, 105.88, 120.57, 121.12, 124.49, 128.44, 129.60, 134.23, 138.24, 138.31, 142.32, 158.91, 160.38, 163.83, 174.65. HRMS m/z calculated for C20H18N5O3S2 [M + H+]: 440.0851, found 440.0856.
The synthetic route of 127-77-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tian, Xinrong; Suarez, Dominic P.; Li, William Hoi Hong; McSherry, Allison K.; Sanchez, Robert M.; Moore, Michael L.; Axten, Jeffrey M.; Tetrahedron Letters; vol. 60; 49; (2019);,
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