Reference of 112101-81-2,Some common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 4-necked 500ml round bottom flask, equipped with Dean-stark apparatus, 150ml of toluene, 24.4gms (0.1mole) of (R)-5-(2-aminopropyl)-2-methoxy benzene sulfonamide of formula-IV and 12.2gms (1.1mole) of 4-hydroxybenzaldehyde are charged. The reaction was carried out azeotrophically and the water (1.8ml) collected and separated. Then the solvent is removed under vacuum at temp max 80C. Cooled to 25-30C. The vacuum is released under N2 atmosphere. A thick oily mass which solidified on storage which is the compound of 2-methoxy-5-(2R)-2-{[(1-E/Z-4-hydroxyphenylmethylene)amino]propyl} benzenesulfonamide of formula-IIIc (35.0gms). Recrystallized sample (from IPA) has the following characteristics. MR : 96-100C 1H [NMR : (200MHz, CDCl3+DMSO-d6) delta 1.23-1.26 (d, 3H), 2.84-2.87 (t, 2H), 3.43-3.52 (m, 1H), 3.92 (s, 3H), 6.0, (broad, 2H), 6.8-7.7 (aromatic, 7H), 7.95 (s, imine, 1H) IR (KBr), 3352, 3257, 2969, 1640, 1606, 1585, 1484, 1394, 1158, 1070, 1018 cm-1
The synthetic route of 112101-81-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NATCO PHARMA LIMITED; WO2004/16582; (2004); A1;,
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