Reference of 154748-63-7, A common heterocyclic compound, 154748-63-7, name is tert-Butyl (3-hydroxycyclobutyl)carbamate, molecular formula is C9H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of tert-butyl (1S,3R)-3-hydroxycyclopentylcarbamate (0.50g, 2.5mmol),4-(trifluoromethyl)phenol (0.49g, 3mmol) and triphenylphosphine (0.98g, 3.75mmol) in anhydrous THF (8mL) was dropwise added DIAD (0.98mL, 4.68mmol) in anhydrous THF (7mL). The reaction solution was stirred at room temperature overnight. The resulting solution was concentrated in vacuo, and the residue was subjected to flash column chromatography on silica gel (eluting with EtOAc-heptane by a gradient of EtOAc from 4% to 32%) to deliver title compound as colorless crystals (0.63g, 73%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Aktas, Bertal H.; Bohm, Andrew; Chorev, Michael; Du, Ronghui; Halperin, Jose; Reis Monteiro dos Santos, Guilherme Rodrigo; Yefidoff-Freedman, Revital; Zhang, Qingwen; European Journal of Medicinal Chemistry; vol. 187; (2020);,
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