Some common heterocyclic compound, 830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, molecular formula is C7H6F3NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H6F3NO2S
Accurate weighing of the quinoline nitrogen oxides (44.3 mg, 0 . 25mmol), 4 – trifluoromethylbenzene sulfonamide (55.0 mg, 0 . 25mmol), double (trifluoroacetic acyloxy) iodobenzene (107.2 mg, 0 . 25mmol), 4 – N – morpholine – phenyl diphenyl phosphine (100.9 mg, 0 . 75mmol), and in turn to 25 ml of the bottle in the Schlenk, adding refined over-dimethyl sulfoxide (3.0 ml), is 120 C in oil bath reaction 30h. After the reaction, the solvent is removed under reduced pressure, the use of petroleum ether/ethyl acetate as eluant, separating by silica gel column, 4 – Trifluoromethyl – N – (quinolin – 2 – yl) benzenesulfonamide of yield is 67%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 830-43-3, its application will become more common.
Reference:
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Zhang Yue; Guo Mingju; (19 pag.)CN104447536; (2017); B;,
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