Some common heterocyclic compound, 116861-31-5, name is tert-Butyl (3-chloropropyl)carbamate, molecular formula is C8H16ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 116861-31-5
[2-Amino-6-(4,5-difluoro-2-hydroxymethylphenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone (?A64?) [0665] 100 mg of [2-amino-6-(4,5-difluoro-2-hydroxymethylphenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone are dissolved in 3 ml of tetrahydrofuran together with 90 mg of tert-butyl (3-chloropropyl)carbamate. 2 ml of sodium hydroxide solution (32%) and 2 mg of tetrabutylammonium iodide are added, and the mixture is stirred at 80 C. for 16 h. The mixture is extracted 3 times with 5 ml of ethyl acetate. The combined organic phases are dried over sodium sulfate. After filtration, the filtrate is evaporated to dryness, the residue is taken up in 3 ml of dichloromethane, and 1 ml of 4N HCl in dioxane is added. After 1 h at 25 C., the mixture is evaporated to dryness in vacuo and purified by chromatography (reversed phase HPLC). [0666] Yield: 18 mg (16%) of {2-amino-6-[2-(3-aminopropoxymethyl)-4,5-difluorophenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone; [0667] LC-MS retention time: 1.66 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 116861-31-5, its application will become more common.
Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; Eggenweiler, Hans-Michael; Sirrenberg, Christian; Buchstaller, Hans-Peter; US2013/178443; (2013); A1;,
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