Electric Literature of 143557-91-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143557-91-9, name is tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Triphenylphosphine (3.57 g, 13.6 mmol) was solved in toluene (40 ml) and cooled to <;20C. Diethylazodicarboxylate (40% in toluene) (6.2 ml, 13.6 mmol) was added to the mixture below 20C, followed by stirring for 10 minutes, endo-3- Hydroxy-8-aza-bicyclo[3.2.1] octane-8-carboxylic acid te/t-butyl ester (2.58 g, 11.3 mmol) was added and after 10 minutes 7-hydroxy-3-methyl-chromen-2-one (2.0 g, 11.3 mmol) was added to the mixture. The temperature raised to 28C due to an exothermic reaction. The mixture was allowed to stir for 15 h at room temperature. Water (50 ml) and sodium hydroxide (20 ml, 0.1 M) was added followed by stirring. The mixture was filtered and washed with water and diethylether. Yield 2.50 g (57%).
The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NEUROSEARCH A/S; PETERS, Dan; NIELSEN, Elsebet, Østergaard; NIELSEN, Karin, Sandager; MUNRO, Gordon; WO2010/130620; (2010); A1;,
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