In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25625-57-4, name is 2-Bromo-N-(3-(trifluoromethyl)phenyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H7BrF3NO
A solution of 3-[3-(2-pyridinyl)phenyl]-1 ,4-diazaspiro[4.5]dec-3-en-2-one (D24) (21 mg) in DMF (4ml) was cooled to 00C. Sodium hydride (2.75mg of 60% in mineral oil, 0.069mmol) was added. The solution was stirred at 00C for 45 minutes before the slow addition (1 hr) of 2-bromo-N-[3-(trifluoromethyl)phenyl]acetamide (D8) (19.40mg) in DMF (1 ml) using a syringe pump. The resulting solution was allowed to warm to room temperature overnight and stirred for another 18 hours. The solution was then cooled again whilst stirring to 00C and sodium hydride (2.75mg, 0.069mmol) was added. Stirring continued for 45 minutes before the slow addition (1 hr) of 2-bromo-N-[3-(trifluoromethyl)phenyl]acetamide (D8) (19.40mg) in DMF (1 ml) using a syringe pump. The resulting solution was allowed to warm to room temperature and stirred over the weekend, then methanol (5ml) was added and the solution was evaporated to dryness, then re-dissolved in DCM (5ml) and water (5ml) was added. The resulting solution was poured through a phase separating cartridge and evaporated to dryness Purification using mass directed auto-purification chromatography gave the title compound as a white solid (22mg). 1H NMR (CD3OD) delta: 1.39-1.51 (3H, m), 1.81-1.91 (3H, m), 1.98-2.10 (assume 4H, m), 4.39 (2H, s), 7.37-7.41 (2H, m), 7.48-7.52 (1 H, t), 7.61-7.65 (1 H, t), 7.56-7.77 (1 H, d), 7.92-7.93 (2H, m), 8.01 (1 H, s), 8.12-8.15 (2H, m), 8.48-8.50 (1 H, m), 8.63-8.97 (1 H, m), 8.98 (1 H, s). Mass Spectrum (Electrospray LC/MS): Found 507 (MH+). C28H25F3N4O2 requires 506. Ret. time 3.14 min.
The synthetic route of 25625-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/34061; (2009); A1;,
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