Electric Literature of 1118-69-0, A common heterocyclic compound, 1118-69-0, name is N-Isopropylacetamide, molecular formula is C5H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a fashion similar to the preparation of 1, treatment of tetrakis(dimethylamido)hafnium (0.200 g, 0.563 mmol) with N-isopropylacetamide (0.228 g, 2.25 mmol) in refluxing toluene (15 mL) for 3 h afforded 6 as colorless crystals (0.219 g, 67%) upon sublimation at 105 C/0.05 Torr: mp 207-210 C; IR (Nujol, cm-1) 1579 (s), 1404 (s), 1365 (s), 1344 (s), 1319 (m), 1188 (s), 1170 (m), 1127 (m), 1053 (m), 988 (m), 887 (m), 823 (m), 816 (m), 618 (s), 584 (s); 1H NMR (C6D6, 23 C, delta) 3.47 (septet, J = 6.5 Hz, 4H, CH(CH3)2), 1.70 (s, 12H, CH3), 1.23 (d, J = 6.5 Hz, 24H, CH(CH3)2); 13C{1H} NMR (C6D6, 23 C, ppm) 182.44 (s, C=O), 48.67 (s, CH(CH3)2), 23.86 (s, CH(CH3)2), 17.37 (s, CH3). Anal. Calcd for C20H40HfN4O4: C, 41.48; H, 6.96; N, 9.68. Found: C, 41.32; H, 6.85; N, 9.77.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Karunarathne, Mahesh C.; Baumann, Joseph W.; Heeg, Mary Jane; Martin, Philip D.; Winter, Charles H.; Journal of Organometallic Chemistry; vol. 847; (2017); p. 204 – 212;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics