Synthetic Route of 147291-66-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of Novabiochem 01-64-0261 commercial resin (2 g, loading : 0,94 mmol/g, 0.0018 mol) was washed with DCM (50 ml), then a solution of 3-tert- butoxycarbonylaminomethylaniline (0.009 mol ) in DCM/CH3COOH 1% (25 ml) was added and the resulting mixture was shaken for 10 minutes at room temperature. Sodium triacetoxyborohydride (0.009 mol) was added, followed by addition of DCM/CH3COOH 1% (25 ml) and the reaction mixture was shaken gently for 48 hours at room temperature. After filtration, the resin was washed 3 times with MeOH and 3 times with DCM, 3x MeOH, 3x DCM, 3x MeOH, 3x DCM, 3x MeOH, 3x DCM, 3x MeOH, 3x DCM, yielding intermediate 30, which was used in next reaction step.
The synthetic route of tert-Butyl 3-aminobenzylcarbamate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/61415; (2006); A1;,
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