Reference of 68524-30-1, These common heterocyclic compound, 68524-30-1, name is 2-[(Diphenylmethyl)thio]acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: VO(acac)2 (2 mol %) and ligand 6 or 10 (3 mol %) were dissolved in CHCl3 (145 muL). The solution turned slightly green-brown after stirring for 60 min. 2-(Benzhydrylthio)acetamide (30 mg, 0.12 mmol) was added, followed by the addition of aqueous H2O2 (30%, 1.2 equiv) in one portion. The reaction mixture was stirred at room temperature for a certain time (see Table 5, entries 2-7). The product was directly purified by column chromatography on silica gel (EtOAc). The isolated enantiomerically-enriched (R)-modafinil was identified through comparison of 1H NMR spectra with literature data (see Ref. 19). The enantiomeric excess of the product was determined by chiral HPLC analysis (Daicel Chiralpak AS, flow 0.9 mL/min, Hex/i-PrOH 60:40, 25 C, 31 bar).
The synthetic route of 68524-30-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Stingl, Kerstin A.; Weiss, Katharina M.; Tsogoeva, Svetlana B.; Tetrahedron; vol. 68; 40; (2012); p. 8493 – 8501;,
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