In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 147291-66-5 as follows. Computed Properties of C12H18N2O2
The oil was dissolved in 100 ml of THF, and 3.66 ml of DIPEA and then dropwise 2.60 g of benzyl isocyanate were added to the solution. The mixture was stirred at RT for 16 h, then under reflux for 6 h and then at RT for a further 16 h. It was concentrated and crystallized from 30 ml of ethyl acetate, and the resulting precipitate was filtered off with suction and dried; 4.90 g; ESI-MS [carbamic acid fragment+H+]=300.
According to the analysis of related databases, 147291-66-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Abbott GmbH & Co. KG; US7105508; (2006); B1;,
Amide – Wikipedia,
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