In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H18N2O2
Example 5 : Synthesis of compounds 7 and 80.17 g (1.5 mmol) N-methylpiperid-4-one and 0.178 g (1.0 mmol) N-Boc-N-methyl-1,2- diaminoethane were reacted with 0.42 g (2.0 mmol) sodium triacetoxyborohydride in 5 ml DCE at RT overnight. The reaction was quenched with MeOH and the mixture extracted with DCM and brine (basified to pH > 12), dried with MgS04 and concentrated in vacuo to give 0.31 g (100%) of 7 as an oil. 1H-NMR (300MHz, CDC13): delta = 1H-NMR (300MHz, CDC13): delta = 1.38 (2, m, CH2), 1.45 (9H, s, Boc), 1.76 (1H, br s, NH), 1.85 (2H, m, CH2), 2.00 (2H, m, CH2), 2.27 (3H, s, MeN), 2.46 (1H, m, CH), 2.76 (4H, m, 2xCH2), 2.86 (3H, s, MeN), 3.30 (2H, t, CH2); MS (ESI) m/z = 272.2 +H+).
The synthetic route of 121492-06-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNTARGA B.V.; BEUSKER, Patrick, Henry; COUMANS, Rudy, Gerardus, Elisabeth; ELGERSMA, Ronald, Christiaan; MENGE, Wiro, Michael, Petrus, Bernardus; JOOSTEN, Johannes, Albertus, Frederikus; SPIJKER, Henri, Johannes; DE GROOT, Franciscus, Marinus, Hendrikus; WO2011/133039; (2011); A2;,
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