Some common heterocyclic compound, 25900-61-2, name is 3-Amino-N-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Amino-N-methylbenzamide
General procedure: To a solution of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-indazole-4-carboxylic acid (8, 30 mg,0.082 mmol) in pyridine (3 mL) at 0 C. POCl3 (12 L, 0.090 mmol) was added, and the mixture wasstirred at 0 C for 1 h. Aniline was added into the reaction mixture and stirred at 0 C for 10 min, then,the mixture was stirred at 25 C for 1.5 h. The reaction was quenched with distilled water, and theorganic phase was washed with water, 1N HCl and brine, dried over Na2SO4, filtered and concentratedin vacuo. The resultant residue was purified by column chromatography to get the final product as awhite solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25900-61-2, its application will become more common.
Reference:
Article; Zhang, Zhen; Zhao, Dongmei; Dai, Yang; Cheng, Maosheng; Geng, Meiyu; Shen, Jingkang; Ma, Yuchi; Ai, Jing; Xiong, Bing; Molecules; vol. 21; 10; (2016);,
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