The important role of

Application of 147356-78-3, The chemical industry reduces the impact on the environment during synthesis 147356-78-3, name is N-Methoxy-N-methylcyclopropanecarboxamide, I believe this compound will play a more active role in future production and life.

Intermediate 402-Cyclopropyl-1H-pyrrolo[2,3-b]pyridine To a stirred mixture of lambda/-boc-2-aminopicoline (10.4g) in dry THF (70ml) in an ice/ salt bath was added, under an atmosphere of nitrogen, n-butyl lithium (2M solution in cyclohexane, 50ml), keeping the temperature below 00C. The reaction was stirred below 00C for 1 h before the addition of a solution of lambda/-methyl-lambda/-(methyloxy)cyclopropanecarboxamide (7.5g) (available from Pfaltz-Bauer) in dry THF (20ml). The reaction mixture was stirred at 00C for 2h then warmed to 100C and poured into 5M hydrochloric acid (130ml). The mixture was heated at 600C for 2h, cooled and the aqueous layer separated. The aqueous layer was basified by the addition of 10M sodium hydroxide, with ice/water cooling, until the pH was 10 – 12. The resulting mixture was extracted with DCM (2x100ml) and the combined organic extracts were washed with water (50ml), dried using a hydrophobic frit and evaporated to give the title compound (7.89g). LC/MS R1 0.78min m/z 159 [MH+]. Method B

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Methoxy-N-methylcyclopropanecarboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics