Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 107017-73-2, name is tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., name: tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate
The N – (4 – fluoro -2 – methoxy -5 – nitro – phenyl) -4 – (6 – methoxy -1 – methyl – 1H – indole -3 – yl) pyrimidine -2 – amine (3 d) (0.42 g, 1.0 mmol) dissolved in tetrahydrofuran (30 ml), is added sodium hydride (0.04 g, 2.0 mmol, w/w=60%), stir at room temperature 30 minutes, add (1 – hydroxy methyl propyl) – tert-butoxycarbonyl amino (0.23 g, 1.5 mmol), continuing stirring at room temperature 5 hours. The addition of water (10 ml) quenching the reaction, concentrated under reduced pressure to remove most of the tetrahydrofuran, is added to the residue in methylene chloride (100 ml), water (50 ml), layered, aqueous phase methylene chloride (100 ml) extraction, the combined organic phase, saturated salt water (50 ml) washing, drying with anhydrous sodium sulfate, concentrated under reduced pressure, to obtain a yellow solid N – [1 – [[5 – methoxy -4 – [[4 – (6 – methoxy -1 – methyl – indole -3 – yl) pyrimidine -2 – yl] amino] -2 – nitro – phenoxy] methyl] cyclopropane alkyl] tert-butyl carbamate (3 e) (0.59 g).
According to the analysis of related databases, 107017-73-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Li Yao; Zhang Guobiao; Hu Shihong; Wei Yonggang; (22 pag.)CN108530428; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics