Adding a certain compound to certain chemical reactions, such as: 7326-73-0, name is 3-(N,N-Dimethylsulfamoyl)benzoic acid, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7326-73-0, name: 3-(N,N-Dimethylsulfamoyl)benzoic acid
To a solution of 3-(dimethylsulfamoyl)benzoic acid (75.72 mg, 330.31 pmol) in DCM (10 ml_) was added HATU (125.59 mg, 330.31 pmol) and DIPEA (155.24 mg, 1 .20 mmol). The solution was stirred for 10 min and then intermediate i-1 b (81 mg, 300.28 pmol) was added. The solution was stirred at 30 C for 12hr. The reaction solution was poured into water (50 ml_) and extracted with EtOAc (100 ml_). The organic layer was washed with brine (50 ml_), dried (Na2SC>4) and concentrated in vacuum. To the residue was added MeOH (20 ml_) and stirred for 20 min, a white solid was formed. The solid was filtered and dried in vacuum to give compound 13 as a white solid. LCMS (ESI) m/z: [M+H]+ = 444.9. 1 H NMR (400 MHz, DMSO-d6) d= 12.49 (s, 1 H), 9.32 (t, J=5.6 Hz, 1 H), 8.27-8.25 (m, 2H), 7.96-7.90 (m, 3H), 7.81 -7.80 (m, 1 H), 7.64 (s, 1 H), 7.46-7.42 (m, 2H), 7.33-7.30 (m, 1 H), 4.23 (d, J=5.6 Hz, 2H), 2.65 (s, 6H) ppm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(N,N-Dimethylsulfamoyl)benzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FOGHORN THERAPEUTICS INC.; ANTHONY, Neville, John; MILLAN, David, Simon; VASWANI, Rishi, G.; SCHILLER, Shawn, E.R.; (239 pag.)WO2019/152437; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics