In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75175-77-8 as follows. HPLC of Formula: C11H12FNO
General procedure: A mixture of compounds 11a-c (0.01 mol) with enaminones 12a-g {e.g., 3-(dimethylamino)-1-phenylprop-2-en-1-one (12a), 3-(dimethylamino)-1-(4-methylphenyl)prop-2-en-1-one (12b),3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one (12c), 1-(4-chlorophenyl)-3-(dimethyl-amino)prop-2-en-1-one (12d), 1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one (12e), 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one (12f) or 3-(dimethylamino)-1-(thiophen-2-yl)prop-2-en-1-one (12g)}(0.01 mol) in glacial acetic acid (25 mL), the reaction mixture was refluxed for 1 h and then left to cool.The solid product was filtered off, washed with ethanol, dried and finally recrystallized from DMF/H2Oto afford the corresponding pyrazolo[1,5-a]pyrimidine derivatives 18a-u.
According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; El-Naggar, Mohamed; Hassan, Ashraf S.; Awad, Hanem M.; Mady, Mohamed F.; Molecules; vol. 23; 6; (2018);,
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