758-96-3, name is N,N-Dimethylpropionamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of N,N-Dimethylpropionamide
Scheme AStep a1a: compound A2 (N,N-2-trimethyl-3-oxopentanamide)32.1 ml (0.35 mol) phosphoryl trichloride (POCI3) were dissolved in 100 mL of toluene. 32.6 ml (0.3 mol) A , V-dimethylpropionamide (A1) (dissolved in 50 mL toluene) were added to the resulting solution under stirring under an inert gas atmosphere. The reaction mixture was heated to 80C for 6 h, allowed to cool to RT and stirred for another 12 h at RT. After evaporation of toluene under reduced pressure, the resulting mixture was stirred for 2 h. 100 mL toluene were then added, the resulting mixture was cooled to below 0C and icy water (100 mL) was added. Then, 24 g of solid NaOH, dissolved in water, were added to the mixture. After 1 h of stirring, 47.7 g Na2C03 as solid were added and the resulting mixture was stirred for 16 h at RT. The organic layer was separated, dried over MgS04 and distilled (0.8 bar, 78-82C). 10.8 g (46%) of A2 was obtained in form of a colorless solid.
The synthetic route of 758-96-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GRUeNENTHAL GMBH; BUSCHMANN, Helmut, Heinrich; HOLENZ, Joerg; WO2011/157390; (2011); A2;,
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