Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7150-72-3, name is tert-Butyl vinylcarbamate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl vinylcarbamate
In a Schlenck tube, tert-butyl N-ethenylcarbamate 7a (1.74 eq., 100 mg, 0.698 mmol) andtBuOK (1.91 eq., 86 mg, 0.766 mmol) were dissolved in DMSO (1 mL) under air atmosphereat 55 C. The mixture was stirred for 1 minute. Then 1,10-phenanthroline (2.6 eq., 188 mg, 1.05mmol) and ((thiophene-2-carbonyl)oxy)copper (1.29 eq., 99 mg, 0.519 mmol) were added. Theresulting mixture was stirred for another minute. Finally (2-bromoethynyl)benzene 8a (1 eq.,72.8 mg, 0.05 mL, 0.402 mmol) as a DMSO solution (1 mL) was added to the mixture. After10 minutes, the reaction was complete as judged by TLC (99:1, petroleum ether:ethyl acetate).The mixture was diluted with EtOAc, filtered over a pad of silica gel, washed with water andthen the organic layer was dried over MgSO4. After filtration, the solvent was removed undervacuum. The crude oil was purified by silica gel chromatography (100:0 to 95:5, petroleum ether:ethyl acetate) to give tert-butyl N-ethenyl-N-(2-phenylethynyl)carbamate 5a (69.5 mg,0.286 mmol, 74%) as slightly yellow oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Le Fouler, Vincent; Duret, Guillaume; Bisseret, Philippe; Blanchard, Nicolas; Tetrahedron Letters; vol. 59; 36; (2018); p. 3349 – 3352;,
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