Application of 869494-16-6, These common heterocyclic compound, 869494-16-6, name is tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a microwave vial a solution of 3 -chloro-4-(6-fluoropyridin-3 -yl)-6-( i-methyl-i Hpyrazol-4-yl)pyrazolo[i,5-a]pyridine (Intermediate P9; 5 mg, 0.015 mmol) and tert-butyl 3,6- diazabicyclo[3.i.i]heptane-6-carboxylate (9.1 mg, 0.046 mmol) in DMSO (0.2 mL) was subjected to microwave irradiation at 130 °C for 5 h and then at 150 °C for 6 h. The reaction mixture was cooled to ambient temperature and then directly purified by reverse phase chromatography (5-95percent ACN/water) to afford the title compound (2.6 mg, 34percent yield). ?H NIVIR (CDC13) 8.51 (d, 1H), 8.34 (d, 1H), 7.88 (s, 1H), 7.76 (s, 1H), 7.65 (m, 2H), 7.12 (d, 1H), 6.62(d, 1H), 4.33 (m, 2H), 4.20 (m, 2H), 3.98 (s, 3H), 3.55 (m, 2H), 1.45 (d, 2H), 1.38 (s, 9H).
Statistics shows that tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate is playing an increasingly important role. we look forward to future research findings about 869494-16-6.
Reference:
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; CHICARELLI, Mark J.; GOLOS, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; (594 pag.)WO2017/11776; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics