Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1118-69-0, name is N-Isopropylacetamide, A new synthetic method of this compound is introduced below., SDS of cas: 1118-69-0
A 100 mL Schlenk flask fitted with a reflux condenser was charged with tetrakis(dimethylamido)zirconium (0.200 g, 0.748 mmol) and toluene (10 mL). A solution of N-isopropylacetamide (0.302 g, 2.99 mmol) in toluene (10 mL) was added slowly and the resultant mixture was refluxed for 3 h. Upon cooling to room temperature, the volatile components were removed under reduced pressure and sublimation of the crude solid at 110 C/0.05 Torr afforded 3 as colorless crystals (0.188 g, 51%): mp 206-209 C; IR (Nujol, cm-1) 1576 (s), 1456 (s), 1403 (s), 1363 (s), 1342 (s), 1319 (m), 1186 (s), 1170 (m), 1126 (m), 1051 (m), 987 (m), 886 (m), 822 (m), 814 (m), 614 (s), 582 (s); 1H NMR (C6D6, 23 C, delta) 3.34 (septet, J = 6.2 Hz, 4H, CH(CH3)2), 1.71 (s, 12H, CH3), 1.24 (d, J = 6.2 Hz, 24H, CH(CH3)2); 13C{1H} NMR (C6D6, 23 C, ppm) 183.00 (s, C=O), 48.94 (s, CH(CH3)2), 23.86 (s, CH(CH3)2), 17.06 (s, CH3). Anal. Calcd for C20H40N4O4Zr: C, 48.85; H, 8.20; N, 11.39. Found: C, 48.69; H, 8.06; N, 11.44.
The synthetic route of 1118-69-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Karunarathne, Mahesh C.; Baumann, Joseph W.; Heeg, Mary Jane; Martin, Philip D.; Winter, Charles H.; Journal of Organometallic Chemistry; vol. 847; (2017); p. 204 – 212;,
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