Synthetic Route of 2895-21-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2895-21-8, name is N-Isopropyl-2-chloroacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(1) The compound 1 (500 mg), the compound 2 (677 mg) and sodium carbonate (529 mg) were suspended inacetonitrile (10 mL), and the reaction mixture was stirred for 18 hours at 60 C. The reaction mixture was cooled toroom temperature, and then diluted with ethyl acetate, washed with water and brine, and dried over anhydroussodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silicagel column chromatography (eluent: ethyl acetate-methanol; gradient: 100:0-95:5) to give the compound 3 (711 mg)as a colorless solid.MS (APCI) 300 [M+H]+
The synthetic route of N-Isopropyl-2-chloroacetamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; USHIROGOCHI, Hideki; SASAKI, Wataru; ONDA, Yuichi; SAKAKIBARA, Ryo; AKAHOSHI, Fumihiko; (158 pag.)EP3135668; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics