107017-73-2, name is tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate
Intermediate 3 (400 mg, 1.6 mmol), tert-butyl [1-(hydroxymethyl)cyclopropyl]carbamate (390.5 mg, 2.01 mmol) andtriphenylphosphine (1683 mg, 6.4 mmol) were combined in THF (10 mL) and cooled to 0 C in an ice bath. DIAD (0.63 mL, 3.2 mmol) was added dropwise and the reaction mixture stirred for 10 mm before being allowed to warm to RT and stirred for a further 96h. The reaction mixture was concentrated under reduced pressure, and purified by Biotage Isolera chromatography (silica gel, eluting with heptaneEtOAc, 1:0 to 1:1). A second purification by Biotage Isolera chromatography (silicagel, eluting with heptane-EtOAc, 20:3) afforded 208.9 mg (23% yield) of the title compound as a colourless oil.LCMS (Analytical Method A) Rt = 1 .47 mm, MS (ESipos): m/z = 419 (M+H)+.
The synthetic route of 107017-73-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
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