Reference of 50667-69-1, A common heterocyclic compound, 50667-69-1, name is 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide, molecular formula is C3H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step i): A mixture of 2,6-dichlororbenzoic acid (4 g; 20,94 mmol), cone. H2S04 (50 mL) and N-(hydroxymethyl)trifluoroacetamide (2,996 g; 20,94 mmol) was stirred at rt overnight. The mixture was diluted with 500 mL crushed ice and 200 mL H20, the precipitate was filtered and dried to give crude 3-(trifluoromethylcarbonylamino-methyl)-2,6-dichloro-benzoic acid.
The synthetic route of 50667-69-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PRIEPKE, Henning; DOODS, Henri; KUELZER, Raimund; PFAU, Roland; STENKAMP, Dirk; ROENN, Robert; PELCMAN, Benjamin; WO2011/48004; (2011); A1;,
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