These common heterocyclic compound, 115643-59-9, name is 2-Amino-6-fluorobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 115643-59-9
General procedure: To a solution of 5-hexynoic acid (3.0 mmol) in dryCH2Cl2 (5 mL) was added EDCI (3.1 mmol) and HOBt(3.1 mmol). The resulting mixture was stirred at rt for 2 h. Then substituted or unsubstituted 2-aminobenzamide (3.0 mmol) wasadded, and the reaction mixture was stirred at rt for 12 h whilebeing monitored by TLC. After the addition of H2O (10 mL) themixture was extracted with ethyl acetate (3 × 20 mL). Theorganic layers were combined and concentrated under vacuumto give the amide intermediate.
The synthetic route of 2-Amino-6-fluorobenzamide has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Hengshuai; Jiao, Shengchao; Chen, Kerong; Zhang, Xu; Zhao, Linxiang; Liu, Dan; Zhou, Yu; Liu, Hong; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 416 – 424;,
Amide – Wikipedia,
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