The important role of

195986-74-4, name is 7-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C9H7BrN2O2

To a solution of 7-bromo-3,4~dihydro-lH-benzo[e][l,4]diazepine-2,5-dione (1 equiv) in dry dioxan (0.1 M) were added bis(pinacolato)diboron (1.1 equiv), potassium acetate (3.5 equiv) and dppf (0.05 equiv). The reaction mixture was degassed with nitrogen for 20 minutes. PdCl2(dppf) (0.05 equiv) was added to the reaction mixture, which was degassed for a further 5 minutes. The reaction was heated to 120 C for 16 hours under nitrogen. The reaction mixture was partitioned between CH2CVMeOH and water. The aqueous phase was further extracted with CH2Cl2MeOH. The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo. The residue was sonicated in hexane/ CH2Cl2, filtered, sonicated in CH2Cl2 and filtered to yield the desired product.7-(4,4,5,5-Tetramethyl-[l,3,2]dioxaborolan-2-yl)-3,4-dihydro-lH-benzo[e][l,4]diazepine-2,5- dione: (63 % yield, 85 % purity main impurity being the boronic acid 15 %) m/z (LC-MS, ESP): 303.4 [M+H]+ R/T = 3.08 min

The synthetic route of 195986-74-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2008/23161; (2008); A1;,
Amide – Wikipedia,
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