Related Products of 683-57-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 683-57-8, name is 2-Bromoacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 4-chloro-5H-pyrrolo [3, 2-d]pyrimidine (1.54 g, 10.0 iranol) , 2-bromoacetamide (1.51 g, 10.9 mmol) , cesium carbonate (3.58 g, 11.0 mmol) and N,N-dimethylformamide (13 mL) was stirred at room temperature for 69 hr. Cesium carbonate (1.30 g, 3.99 mmol) was added, and the reaction mixture was stirred at room temperature for 24 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (chi7) . The organic layers were combined, dried over anhydrous magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to give the title compound (1.81 g, 86%) as a yellow solid.1H-NMR (DMSOd6, 300 MHz) delta 5.14 (2H, s) , 6.73 (IH, d, J = 3.3 Hz), 7.30 (IH, br s) 7.68 (IH, br s) , 7.95 (IH, d, J = 3.3 Hz) , 8.61 (IH, s) .
The synthetic route of 2-Bromoacetamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/4749; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics