Related Products of 459817-82-4, The chemical industry reduces the impact on the environment during synthesis 459817-82-4, name is tert-Butyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide, I believe this compound will play a more active role in future production and life.
Compounds 6 and 7 were obtained by the standard procedures as outlined abovewithout purification of aldehyde 6. Compound 7 was purified with flash-chromatography with 11 % overall Yield: over 2 stages after purification. Alkylation of 7 with 3 was conducted in DMF at room temperature with 1.2 eq of NaH (mixed at 0C then stirred atambient temperature for 18 h). Compound 8was purified by flash-chromatography(hexane-ethyl acetate 1: 3) with resulted 100% purity; yield: 32%. After hydrolysis ofthe Boc-protection the resulting title compound was purified with HPLC chromatography; yield: 74%. H PLC-MS (Positive mode) mlz 372 (M+H). Retention time1.083mm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe David; (187 pag.)WO2018/229193; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics