Electric Literature of 83922-54-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83922-54-7 name is 4-(Methylsulfonamido)benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1) diethyl (hydroxy (4- (methylsulfonamido) phenyl) methyl) phosphonate To a mixture of N- (4-formylphenyl) methanesulfonamide (2 g, 10 mmol) and diethyl phosphate (1.4 g, 10 mmol) was added a solution of sodium methoxide in methanol (0.5 mL, 0.25 mmol) . The mixture was stirred at rt for 12 hours. The reaction mixture was diluted with dichloromethane (20 mL) and washed with saturated aqueous NH4Cl (10 mL) , and dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE : EtOAc (V : V) 10 : 1 to give diethyl (hydroxy (4- (methylsulfonamido) phenyl) methyl) phosphonate as gray oil (2.9 g, 87) .[1120]MS (ESI, pos. ion) m/z: 338.3 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Methylsulfonamido)benzaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; XIE, Hongming; WU, Xiwei; REN, Qingyun; ZHANG, Jiancun; (236 pag.)WO2015/197028; (2015); A1;,
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