Application of 96-30-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96-30-0, name is 2-Chloro-N-methylacetamide, This compound has unique chemical properties. The synthetic route is as follows.
Example 3 2-(7-(4-chlorobenzyl)-3-methyl-2,6-dioxo-8-(3-(trifluoromethyl)phenoxy)-2,3,6,7- tetrahydro- 1 H-purin- 1 -yl)-N-methylacetamide The title compound was prepared using the method of example 2 except a catalytic amount of TBAI was added to give 2-(7-(4-chlorobenzyl)-3-methyl-2,6-dioxo-8-(3- (trifluoromethyl)phenoxy)-2,3,6,7-tetrahydro-lH-purin-l -yl)-N-methylacetamide (36 mg, 62.1 % yield) as white solid. ‘H-NMR (DMSO-^) delta 7.97-7.98 (m, 1H), 7.79 (s, 1H), 7.69-7.74 (m, 3H), 7.44 (s, 4H), 5.45 (s, 2H), 4.43 (s, 2H), 3.91 -3.93 (q, 2H), 3.29 (s, 3H), 2.58-2.59 (d, 3H). LCMS retention time 2.547 min; LCMS MH”1’ 522.
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-N-methylacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; HYDRA BIOSCIENCES, INC.; CHENARD, Bertrand; GALLASCHUN, Randall; WO2014/143799; (2014); A2;,
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