Adding a certain compound to certain chemical reactions, such as: 676371-64-5, name is Methyl 3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 676371-64-5, Quality Control of Methyl 3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylate
methyl 3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylate (50.0 mg, 0.207 mmol, SpiroChem) in anhydrous THF (3 mL) under N2 and at 0 C was treated dropwise with methylmagnesium bromide (3.0M in ether, 0.345 mL, 1.04 mmol). After complete addition, the ice bath was removed, and the solution was stirred with warming to room temperature overnight. The reaction was quenched by the addition of sat. NH4CI solution (5 mL). The mixture was extracted with two portions of EtOAc. The combined organic extracts were dried over MgSCL, filtered and concentrated. To the crude mixture in DCM (2 mL) was added TFA (0.160 mL, 2.07 mmol), and the reaction was stirred for 1Hour. Solvent was removed in vacuo to afford a clear oil which was used without further purification. Theoretical yield was assumed.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; INCYTE CORPORATION; SHVARTSBART, Artem; COMBS, Andrew, P.; FALAHATPISHEH, Nikoo; POLAM, Padmaja; SHAO, Lixin; SHEPARD, Stacey; (170 pag.)WO2019/126505; (2019); A1;,
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