Adding a certain compound to certain chemical reactions, such as: 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112257-19-9, Application In Synthesis of tert-Butyl methyl(2-(methylamino)ethyl)carbamate
Step 4 Synthesis of (2S,3R,4S,5S,6S)-2-(((S)-6-(5-((S)-4-(((2-((tert-butoxycarbonyl)(methyl)amino)ethyl)(methyl)carbamoyl)oxy)-8-(chloromethyl)-1-methyl-7, 8-dihydro-6H-thieno[3,2-e]indol-6-yl)-5-oxopentanoyl)-8-(chloromethyl)-1-methyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-yl)oxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate (47) To a solution of 46 (50 mg, 0.054 mmol) in THF (3 mL) at 0° C., was added a solution of 4-nitrophenyl chloroformate (22 mg, 0.10 mmol) in DCM (0.5 mL), followed by DIPEA (57 uL, 0.33 mmol), and the mixture was stirred at 0° C. for 1 h. To the above mixture was added a solution of 38 [prepared as described J. Med. Chem. 1992, 33, 559-567] (31 mg, 0.16 mmol) in THF (0.5 mL), and the mixture was stirred at 0° C. for 30 min and concentrated in vacuo, and the residue was purified was purified by silica gel chromatography using a gradient of EtOAc (0-100percent) in heptanes to give the product 47 as white solid 56 mg (91percent). LC-MS (Protocol B): m/z 1150.2 [M+NH4], retention time=1.14 minutes
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl methyl(2-(methylamino)ethyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pfizer Inc.; MADERNA, Andreas; SUBRAMANYAM, Chakrapani; TUMEY, Lawrence N.; CHEN, Zecheng; CASAVANT, Jeffrey M.; (187 pag.)US2016/271270; (2016); A1;,
Amide – Wikipedia,
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