Synthetic Route of 144-80-9, These common heterocyclic compound, 144-80-9, name is N-((4-Aminophenyl)sulfonyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Two to three drops of conc. H2SO4 (8-9 mmol) was added to a solution of sulpha drug (3 mmol) and water (5 mL) and kept on an ice bath. A cold solution of NaNO2 (0.207 g, 3 mmol) was added drop-wise to it by maintaining the temperature of the reaction up to 5C. After completion of addition, the solution was kept for 15 min with occasional stirring to complete the diazotization reaction. To the ice cold solution of a above prepared Schiff?s base (3 mmol) with ethanol and 10% of 20 mL of aqueous NaOH, individual diazotised sulpha drugs was poured. The resultant mixture was stirred and allowed to stand in an ice bath for 1 h and the pH was maintained at 5-6 by occasional and controlled addition of dilute HCl. Then the coloured products obtained were filtered, washed repeatedly with water and dried. The progress of reaction was monitored by TLC using suitable solvent system ethyl acetate and cyclohexanol. Finally the products were purified by recrystallization from ethanol.
Statistics shows that N-((4-Aminophenyl)sulfonyl)acetamide is playing an increasingly important role. we look forward to future research findings about 144-80-9.
Reference:
Article; Sarangi, Priyambada Kshiroda Nandini; Sahoo, Jyotirmaya; Behera, Somalisa; Paidesetty, Sudhir Kumar; Mohanta, Guru Prasad; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 56B; (2017); p. 1256 – 1264;,
Amide – Wikipedia,
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