Electric Literature of 16091-26-2,Some common heterocyclic compound, 16091-26-2, name is 3′-Aminobenzanilide, molecular formula is C13H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 mL three-necked flask equipped with a stirrer, a thermometer and a reflux condenser (with a water separator), 130.0 g of methyl chloroacetate was added.42.4 g of m-anilinoaniline was added under stirring.24.5 g of sodium carbonate was uniformly mixed under stirring, and the temperature was raised to 100 to 105 C, and refluxed for 2.0 h. 4.2 g of potassium bromide and 0.3 g of zinc powder were added, and the mixture was refluxed at 110 to 130 C for 3.0 h. The sample was sampled and detected by high pressure liquid chromatography, and the purity of the target product was 99.2%. After methyl chloroacetate was distilled off under reduced pressure, acetic acid was added to obtain an acetic acid solution of m-benzoylamino-N,N-di(methyl acetate) aniline in a yield of 98.4%.
The synthetic route of 16091-26-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Central South University of Forestry and Technology; Zhao Ying; Hu Renjie; Xiong Yuanfu; Zhao Qi; Yuan Yao; Tan Xiaoyan; (8 pag.)CN109796365; (2019); A;,
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