Application of 99733-18-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-(4-((5-(((5-(/tvV-butyl (oxazol-2-yl (methyl (thio)thiazol -2- yl)carbamoyl)piperidin-l-yl)acetic acid (200 mg, 0. 46 mmol) in DMF (5 mL) was added tert- butyl (7-aminoheptyl)carbamate (126 mg, 0.55 mmol) and DIEA (118 mg, 0.92 mmol), followed by HOBt (93 mg, 0.69 mmol) and EDCTHCl (133 mg, 0.69 mmol). After overnight at RT, the mixture was diluted with H2O and extracted with EA. The combined organic layers were washed with saturated NaHC03, dried over Na2S04, filtered and concentrated to give the crude product, which was purified using silica gel eluting with MeOH/DCM (0% to 10%) to give /c/V-butyl (7- (2-(4-((5-(((5-(/er/-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)carbamoyl)piperidin-l- yl)acetamido)heptyl)carbamate (243 mg, 82% yield) as a solid. MS (ESI) m/z 651.2 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis tert-Butyl (7-aminoheptyl)carbamate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle W.H.; CHOURASIA, Aparajita Hoskote; ERDMAN, Paul E.; FUNG, Leah; HECHT, David Aaron; MERCURIO, Frank; SULLIVAN, Robert; VACCA, Joseph P.; (156 pag.)WO2020/23782; (2020); A1;,
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