Analyzing the synthesis route of 1,1,1-Trifluoro-N-phenylmethanesulfonamide

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 456-64-4, name is 1,1,1-Trifluoro-N-phenylmethanesulfonamide, A new synthetic method of this compound is introduced below., Recommanded Product: 456-64-4

Compound 60; N-phenytrifluoromethanesulfonimide (3.336 g, 9.337 mmol, 1.1 eq.) was added to Compound 53 (2.37 g, 8.488 inmol, 1.0 eq.) in 100 mL DCM, followed by Cs2CO3 (3.04 g, 1.1 eq.). The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was filtered through CELITE and concentrated. The residue was purified by silica gel chromatography (30-60% EtOAc/hexane) to give Compound 60 as the white solid (3.2 g, 92%). 1H NMR (300 MHz, CDCl3): delta 7.37 (d, 2 H), 7.20 (d, 2 H), 4.50 (m, 1 H), 4.18 (m, 1 H), 3.03 (m, 1 H), 2.98 (m, 2 H), 2.85 (m, 1 H), 2.62 (m, 1 H), 1.39 (s, 9 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GILEAD SCIENCES, INC.; WO2008/11117; (2008); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics