Adding a certain compound to certain chemical reactions, such as: 42137-88-2, name is N,N-Bis(2-chloroethyl)-4-methylbenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 42137-88-2, Recommanded Product: N,N-Bis(2-chloroethyl)-4-methylbenzenesulfonamide
Alternatively, Intermediate 1 can be prepared from commercially available starting materials 5-iodo-methoxyaniline and N,N-bis(2-chloroethyl)-4-methylbenzenesulfonamide. Treatment of 5-iodo-methoxyaniline and N,N-bis(2-chloroethyl)-4-methylbenzenesulfonamide with sodium carbonate and potassium iodide in cyclohexanol at 160 C. will provide 1-(5-iodo-2-methoxyphenyl)-4-tosylpiperazine. Coupling of 1-(5-iodo-2-methoxyphenyl)-4-tosylpiperazine with sodium 3-(difluoromethoxy)benzenesulfinate can be accomplished by treatment with Xantphos, cesium carbonate, and tetrabutyl ammonium chloride. The resulting 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-tosylpiperazine can be converted to Intermediate 1 by treatment with concentrated sulfuric acid at 50 C. for 5 hours.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Bis(2-chloroethyl)-4-methylbenzenesulfonamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Black, Lawrence A.; US2014/120036; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics