Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138-41-0, name is Carzenide, A new synthetic method of this compound is introduced below., Safety of Carzenide
General procedure: To a stirred solution of the carboxylic acid (1.0 mmol) in anhydrous CH2Cl2 (5 mL), the appropriate amine or its hydrochloric acid(1 mmol), Et3N (1 eq, 0.14 mL, 1 mmol or 2 eq, 0.28 mL, 2 mmol in caseof hydrochloric acid), HOBt (1 eq, 140 mg, 1 mmol) and EDCI (1.1 eq,211 mg, 1.1 mmol) were added at 0 C. The reaction mixture was stirred overnight at room temperature and then the solvent was removedunder reduced pressure. The residue was dissolved in AcOEt and washedwith H2O, 5% H2SO4, H2O, 5% NaHCO3, brine and H2O. In thecase of proline washing with 5% H2SO4, was omitted. The product was obtained after drying the organic phase over anhydrous Na2SO4, evaporation of the solvent under reduced pressure, and purification by column chromatography.
The synthetic route of 138-41-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Afantitis, Antreas; Aidinis, Vassilis; Gerokonstantis, Dimitrios Triantafyllos; Kokotos, George; Magkrioti, Christiana; Moutevelis-Minakakis, Panagiota; Nikolaou, Aikaterini; Bioorganic and medicinal chemistry; vol. 28; 2; (2020);,
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