Application of 116861-31-5, The chemical industry reduces the impact on the environment during synthesis 116861-31-5, name is tert-Butyl (3-chloropropyl)carbamate, I believe this compound will play a more active role in future production and life.
[0095] Berbamine dihydrochloride (7.0 g, 10.28 mmol) is dissolved in N,N-dimethyl formamide (150 mL). Under nitrogen atmosphere, the solution is cooled to 0 C. After adding NaH (1.65 g, 60%, 41.12 mmol) into the solution, the mixture is stirred for 1 hour, then the solution of compound (8-2) (2.18 g, 11.3 mmol) in N,N-dimethyl formamide (30 mL) is added dropwise therein over 15 minutes. After being stirred for 1 hour at 0 C., the mixture is allowed to be warmed up to room temperature and is stirred for 3 hours, then is heated to 80 C. overnight. After vacuum evaporation, the reaction mixture is diluted with water and extracted with dichlorometbane (3*150 mL). The combined organic phase is washed with water and brine, dried through, anhydrous sodium sulfate and filtered. After vacuum concentration, the residue is purified by a preparative high performance liquid chromatography to give compound (8-3) (3.0 g, 38.1%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (3-chloropropyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HANGZHOU BENSHENG PHARACEUTICALS CO., LTD.; Xu, Rongzhen; Xie, Fuwen; Lai, Hongxi; Rong, Frank; US2013/178470; (2013); A1;,
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