Related Products of 177906-48-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 177906-48-8 name is trans-N-Boc-1,4-cyclohexanediamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Synthesis of compound 13.2. To a solution of compound 13.1 (6.43 g, 30.00 mmol, 1.00 equiv) in 80 mL of distilled THF was added LiAlH4 (5.7 g, 168.03 mmol, 5.00 equiv) portion-wise at 0C under nitrogen. After addition completion, the resulting mixture was stirred for 4 h at 80C in an oil bath. The reaction was then quenched with Na2SO4 10H2O and the solids were filtered out, washed with 100 mL of THF and the filtrate was concentrated under vacuum to give 3.5 g of trans- l-N-methylcyclohexane-l,4-diamine, compound 13.2 as a white solid
At the same time, in my other blogs, there are other synthetic methods of this type of compound, trans-N-Boc-1,4-cyclohexanediamine, and friends who are interested can also refer to it.
Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; SHELLEY, Mee; MASSE, Craig E.; HARRIMAN, Geraldine C.; WO2015/164374; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics