Synthetic Route of 122334-37-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 122334-37-6 as follows.
In a dry round bottom flask is added in excess of the cutting and 1000 ml tetrahydrofuran, then dropwise 1 – bromo ethyl cyclopropane (1 muM), the resulting mixture at room temperature under stirring for 3 hours, the reaction is filtered, to remove the magnesium chips, formula (II) compound of tetrahydrofuran solution (1 mol/L). The reaction is as followsThe embodiment 1 to obtain the compounds of formula (I) compound structure (0.10 muM), tetrahydrofuran (250 ml) are added to a reaction in the bottle, in the -20 C dropping embodiment 2 of formula (II) to obtain a compound of tetrahydrofuran solution 100 ml, then completing, at this temperature to continue the reaction […] 3 hr, the reaction after the reaction is dropped to 250 ml with cold water, then completing, filtering to remove the solid, the collection of organic phase, drying and reducing pressure concentration and crystallization, shall be 1 – (4 – chlorophenyl) -2 – cyclopropyl -1 – acetone product 18.4 g, in formula (I) compounds of structure the idea receives rate is 88.2%, HPLC purity through detection of 99.3%.
According to the analysis of related databases, 122334-37-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Weifang Runfeng Chemical Co., Ltd.; Sun Guoqing; Hou Yongsheng; Song Jian; (7 pag.)CN108610246; (2018); A;,
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