Introduction of a new synthetic route about C11H20N2O2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 201162-53-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 201162-53-0, name is 3-Boc-3,8-Diazabicyclo[3.2.1]octane, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C11H20N2O2

General procedure: A 30 mL microwave tube was charged with 3-chloro-7-iodo-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[2,3-b]pyrazine (2.90 g, 7.08 mmol), tert-butyl N-(endo-8-azabicyclo[3.2.1]octan-3-yl)carbamate (3.20 g, 14.2 mmol) and NMP (6.0 mL). The vessel was de-gassed and back-filled with N2 (3x). Di-isopropylethylamine (2.47 mL, 14.2 mmol) was added and the tube was capped, sealed and heated to 150C for 3 days in a sand bath. After cooling, the reaction was diluted with EtOAc, then washed with brine/sat. aq. NH4CI (3x). The organic phase was dried (MgSO4) and evaporated. The residue waspurified by column chromatography on silica gel (gradient elution, 5-35% EtOAc/petrol) to give the title compound (2.59 g). MS: [M+H] = 600.2.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 201162-53-0.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; TAIHO PHARMACEUTICAL CO., LTD.; JOHNSON, Christopher Norbert; BUCK, Ildiko Maria; CHESSARI, Gianni; DAY, James Edward Harvey; FUJIWARA, Hideto; HAMLETT, Christopher Charles Frederick; HISCOCK, Steven Douglas; HOLVEY, Rhian Sara; HOWARD, Steven; LIEBESCHUETZ, John Walter; PALMER, Nicholas John; ST DENIS, Jeffrey David; TWIGG, David Geoffrey; WOODHEAD, Andrew James; (377 pag.)WO2019/167000; (2019); A1;,
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