Synthetic Route of 94838-59-2, A common heterocyclic compound, 94838-59-2, name is tert-Butyl 4-aminophenethylcarbamate, molecular formula is C13H20N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of [2-(4-amino-phenyl)-ethyl]-carbamicacid te/t-butyl ester (2.32 g,9.82 mmol) in N,N-dimethylformamide (DMF) (50 ml) 18-crown-6 (50 mg) was added. At 00C potassium te/t-butylate (1.10 g, 9.82 mmol) was added and the mixture stirred for 30 min. After the addition of allylbromide (1.19 g, 9.82 mmol) the mixture was stirred at room temperature for 16 h. After concentration in vacuo the residue was partitioned between ethyl acetate and saturated aqueous Na-HCO3. The organic layer was washed with water, dried over MgSO4, filtered and the solvent evaporated under reduced pressure to give the product as a red oil (2.50 g, 92%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ABBOTT GMBH & CO. KG; WO2006/40179; (2006); A1;,
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