These common heterocyclic compound, 60144-53-8, name is tert-Butyl (4-fluorophenyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 60144-53-8
A one-pot procedure to synthesize 4-fluoroaniline (3-98) from N-Boc-aniline (3-103c) and iV-Boc-4-/er/-butylaniline (3-105c) was developed (Scheme 4). Thus, treatment of N-Boc- aniline (3-103c) and iV-Boc-4-te t-butylaniline (3-105c) using the above standard fluorination conditions followed by the addition of 10% TFA gave the desired4-fluoroaniline (3-98) in 15% and 37% yields over the two steps, respectively. (Reagent and conditions. PhI(OAc)2 (1 equiv), HF-py (4 equiv), CH2C12 (0.1 M), 25 C, 30 min; then 10% TFA/CH2C12, 15 min, 25 C, 15% (from 3-103c), 37% (from 3-105c).)
The synthetic route of tert-Butyl (4-fluorophenyl)carbamate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ISIS INNOVATION LIMITED; GOUVERNEUR, Veronique; LI, Lei; LIM, Yee-Hwee; HUIBAN, Mickael; WO2012/4567; (2012); A2;,
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