Related Products of 16982-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16982-21-1, name is Ethyl 2-amino-2-thioxoacetate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of ethyl thiooxamate (0.40 g, 3.0 mmol) and 2-Bromoacetophenone (0.60 g, 3.0 mmol) in ethanol (20 ml) was heated to reflux for 6 h. The reaction mixture was concentrated in vacuo, then diluted with ethyl acetate (30 ml), and washed with 1N NaHCO3 (3 × 20 mL) and brine (2 × 20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure. The crude product was purified by silica gel column chromatography using a mixture of petroleum ether/ethyl acetate (20:1, v/v) as eluent to afford the desired product (0.52 g, 74%) as a white solid. 1H NMR (300 MHz, DMSO-d6) delta: 8.55 (s, 1H), 8.08, 8.06 (dd, J = 1.7, 7.6 Hz, 2H), 7.52-7.39 (m, 3H), 4.42 (q, J = 7.1 Hz, 2H), 1.37 (t, J = 7.1 Hz, 3H).
The synthetic route of Ethyl 2-amino-2-thioxoacetate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Xue; Deng, Liming; Nie, Lu; Chen, Yueming; Liu, Yanzhi; Xie, Rongrong; Li, Zheng; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 525 – 528;,
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